Any known issues with in-place upgrade of a 2 node 2012 AG to 2016?

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Any known issues with in-place upgrade of a 2 node 2012 AG to 2016?

I have a 2 node, SQL 2012 AG running in asynchronous mode.  I will be upgrading it to SQL 2016 using the rolling method, upgrading the secondary node first, then failing the primary over to it, and then upgrading the new secondary.  Are there an

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